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    • 专利摘要:
    the present disclosure relates to the use of a compound of formula I as a seed treatment to prevent or control plant diseases. an embodiment of the present disclosure may include a method for controlling or preventing fungal attack on a plant, the method including the steps of applying a fungicidally effective amount of a compound of formula I to a seed adapted to produce the plant.
    公开号:BR112017013733B1
    申请号:R112017013733-0
    申请日:2015-12-18
    公开日:2021-08-10
    发明作者:Carla J.R. Klittich；Chenglin Yao；W. John OWEN
    申请人:Adama Makhteshim Ltd；
    IPC主号:
    专利说明:

    [001] CROSS REFERENCE TO RELATED ORDERS
    [002] This application claims the benefit of U.S. Provisional Patent Application 62/096301, filed on December 23, 2014, which is expressly incorporated by reference herein.
    [003] FIELD
    [004] The present disclosure relates to methods to control phytopathogenic fungi by treating seeds with an innovative seed treatment fungicide.
    [005] BACKGROUND
    [006] In agriculture, seed treatments or seed coatings have been used to treat seeds prior to planting. The term "seed treatment" includes all suitable seed treatment techniques known in the art, such as seed filming, seed coating, seed sweeping, seed soaking (dipping), seed foaming (i.e., covered with foam) and seed pelletization, and refers, preferably, to the application of a compound (or compounds) that are fungicidally active directly on the seeds themselves, before planting and/or in the immediate vicinity during planting.
    [007] SUMMARY
    [008] One embodiment of the present disclosure may include a method for controlling or preventing fungal attack on a plant, the method including the steps of applying a fungicidally effective amount of a compound of Formula I to a seed adapted to produce the plant .

    [009] One aspect of the present disclosure is a method for controlling phytopathogenic fungi in and/or on a plant, with the seeds, from which the plant is expected to grow, before sowing and/or after pre-germination, are treated with a compound of Formula I, wherein: R1 is selected from H, C1-C6 alkyl and C1-C6 alkoxy, and R2 is selected from C1-C6 alkyl, phenyl, benzyl and -CH3-thiophenyl .
    [010] In an exemplary embodiment, a method of treating a plant seed to produce a plant resistant to fungal attack, wherein the plant seed is treated with a compound of Formula I. In a more particular embodiment, R1 and R2 are independently selected from C1-C6 alkyl. In an even more particular embodiment, R1 and R2 are each -CH3.
    [011] In another more particular embodiment of any of the above embodiments, the compound of Formula I is applied at a rate of from about 0.5 to about 500 grams per 100 kilograms of seed.
    [012] In another more particular modality among any of the above modality, the seed that is treated is a wheat seed (Triticum sp.; TRZSS).
    [013] In another more particular modality among any of the above modalities, the fungal pathogen be selected from the group consisting of the causative agent of wheat septoria (Zymoseptoria tritici), sugar beet cercosporiosis (Cercospora beticola) and cercosporiosis of peanuts (Cercospora arachidicola and Cercosporidium personatum).
    [014] In another modality, a plant seed adapted to produce a plant resistant to fungal and insect attack is provided. In an exemplary embodiment, the plant seed is treated with a compound of Formula I and one or more insecticides. In a more particular embodiment, R1 and R2 are each -CH3.
    [015] In another modality, a plant seed adapted to produce a plant resistant to fungal and insect attack is provided. In an exemplary embodiment, the plant seed is treated with a compound of Formula I and one or more fungicides. In a more particular embodiment, R1 and R2 are each -CH3.
    [016] In another modality, a plant seed adapted to produce a plant resistant to fungal and insect attack is provided. In an exemplary embodiment, the plant seed is treated with a compound of Formula I and one or more insecticides. In a more particular embodiment, R1 and R2 are each -CH3.
    [017] In another modality, a plant seed adapted to produce a plant resistant to fungal attack is provided. Plant seed is treated with a compound of Formula I and with one or more additional health enhancers selected from the group consisting of organic compounds, inorganic fertilizers or micronutrient donors, biological control agents and inoculants. In a more particular embodiment, R1 and R2 are each -CH3.
    [018] In another embodiment, a method for treating a plant seedling to produce a plant resistant to fungal attack is provided. The plantlet plant is treated with a compound of Formula I. In a more particular embodiment, R1 and R2 are each -CH3. In another more particular modality among any of the above modality, the seedling is a wheat seedling (Triticum sp.; TRZSS). In another, more particular modality among any of the above modality, the fungal pathogen will be selected from the group consisting of the causative agent of wheat septoria (Zymoseptoria tritici), sugar beet cercosporiosis (Cercospora beticola) and peanut cercosporiosis (Cercospora arachidicola and Cercosporidium personatum).
    [019] In another modality, a plant seedling adapted to produce a plant resistant to fungal and insect attack is provided. In an exemplary embodiment, the plant seedling is treated with a compound of Formula I and one or more insecticides. In a more particular embodiment, R1 and R2 are each -CH3.
    [020] In another embodiment, a plant seedling adapted to produce a plant resistant to fungal and insect attack is provided. In an exemplary embodiment, the plant seedling is treated with a compound of Formula I and one or more fungicides. In a more particular embodiment, R1 and R2 are each -CH3.
    [021] In another embodiment, a plant seedling adapted to produce a plant resistant to fungal and insect attack is provided. In an exemplary embodiment, the plant seedling is treated with a compound of Formula I and one or more insecticides. In a more particular embodiment, R1 and R2 are each -CH3.
    [022] In another embodiment, a plant seedling adapted to produce a plant resistant to fungal attack is provided. The plant seedling is treated with a compound of Formula I and with one or more additional health enhancers selected from the group consisting of organic compounds, inorganic fertilizers or micronutrient donors, biological control agents and inoculants. In a more particular embodiment, R1 and R2 are each -CH3.
    [023] In another embodiment, a plant seedling is adapted to produce a plant resistant to fungal attack. The plantlet plant is treated with a compound of Formula I. In a more particular embodiment, R1 and R2 are each -CH3.
    [024] In another embodiment, a method to protect a plant from fungal attack is provided. The method comprises applying a compound of Formula I to the seedling environment. In a more particular embodiment, the compound of Formula I is provided as a liquid formulation. In another more particular embodiment, the compound of Formula I is provided as a solid formulation.
    [025] Additional features and advantages of the present disclosure will become apparent to those skilled in the art upon consideration of the following detailed description of the illustrative embodiments that exemplify the preferred embodiment for realizing the utility model described in this document as currently considered.
    [026] DETAILED DESCRIPTION OF THE DISCLOSURE
    [027] The modalities of disclosure described herein are not intended to be exhaustive or to limit disclosure to the specific forms disclosed. Rather, the modalities selected for description were chosen to allow a person skilled in the art to practice disclosure.
    [028] Seed treatment may independently include applying a compound of Formula I directly to the seed as a coating or applying to the seed environment as a solid or liquid formulation. Additionally, a compound of Formula I can be applied as a solid or liquid formulation in a seedling environment.
    [029] A seed is broadly interpreted to include anything that can be sown and can potentially be placed in position (ground) for a crop to grow. The term "seed" encompasses plant seeds and propagules of all types including, but not limited to, true seeds, seed pieces, grains, suckers, corms, bulbs, fruit, tubers, cuttings, cutting shoots and similar shapes, and rather means a true seed.
    [030] A seedling is a germinated seed.
    [031] A seedling environment is the soil or other growing medium that surrounds the seedling.
    [032] The present disclosure contemplates all vehicles by which a compound of Formula I can be formulated for delivery and use as a seed treatment fungicide. Conventional seed treatment formulations include, for example, flowable concentrates, solutions, dry treatment powders, water dispersible powders for slurry treatment, water soluble powders and emulsion and gel formulations. These formulations can be applied diluted or undiluted.
    [033] Typically, formulations are applied after diluting the concentrated formulation with water as aqueous solutions, suspensions or emulsions, or combinations thereof. Such solutions, suspensions or emulsions can be produced from water-soluble formulations, which are capable of being suspended in water or emulsifiable, or combinations thereof, which are solids, which include and are commonly known as wettable powders or water-dispersible granules; or liquids which commonly include are known as emulsifiable concentrates, aqueous suspensions or suspension concentrates, and aqueous emulsions or water emulsions, or mixtures thereof such as suspension emulsions. As will be readily appreciated, any material to which this composition can be added can be used, as it yields the desired utility model without significant interference with the desired activity of the pesticide active ingredients as pesticidal agents, improves residual shelf life or decreases the effective concentration required to achieve the pesticidal effect.
    [034] Wettable powders, which can be compacted to form water-dispersible granules, comprise an intimate mixture of one or more of the pesticide active ingredients, an inert carrier and surfactants. The concentration of the pesticidal active ingredient in the wettable powder is usually from about 10 percent to about 90 percent by weight based on the total weight of the wettable powder, more preferably about 25 percent by weight to about 75 percent by weight. Weight. In preparing wettable powder formulations, pesticide active ingredients can be combined with any finely divided solid, such as pyrophyllite, talc, chalk, gypsum, Fuller's earth, bentonite, attapulgite, starch, casein, gluten, montmorillonite clays, earths of diatoms, purified silicates or the like. In such operations, the finely divided carrier and surfactants are typically mixed with the compound (or compounds) and ground.
    [035] Emulsifiable concentrates of the pesticide active ingredient comprise a convenient concentration, such as from about 10 percent by weight to about 50 percent by weight of the pesticide active ingredient, in a suitable liquid, based on the total weight of the concentrate. The pesticide active ingredients are dissolved in an inert carrier, which is a water-miscible solvent or a mixture of water-immiscible organic solvents and emulsifiers. Concentrates can be diluted with water and oil to form spray mixtures in the form of oil-in-water emulsions. Useful organic solvents include aromatics, especially the high-boiling olefinic and naphthalene petroleum moieties, such as heavy aromatic naphtha. Other organic solvents can also be used, such as, for example, terpenic solvents, which include rosin derivatives, aliphatic ketones, such as cyclohexanone, and complex alcohols, such as 2-ethoxyethanol.
    [036] Emulsifiers that can be employed to advantage herein can be readily determined by those skilled in the art and include various nonionic, anionic, cationic and amphoteric emulsifiers, or a mixture of two or more emulsifiers. Examples of nonionic emulsifiers useful for preparing emulsifiable concentrates include polyalkylene glycol ethers and condensation products of alkyl and aryl phenols, aliphatic alcohols, aliphatic amines or fatty acids with ethylene oxide, propylene oxides such as ethoxylated alkyl phenols and carboxylic esters esterified with the polyol or polyoxyalkylene. Cationic emulsifiers include quaternary ammonia compounds and fatty amine salts. Anionic emulsifiers include the oil-soluble (e.g., calcium) salts of alkylaryl sulfonic acids, oil-soluble salts of sulfated polyglycol ethers, and appropriate phosphate polyglycol ether salts.
    [037] Representative organic liquids that can be used in the preparation of emulsifiable concentrates are aromatic liquids such as xylene, propyl benzene fractions; or mixed naphthalene fractions, mineral oils, substituted aromatic organic liquids such as dioctyl phthalate; kerosene; dialkyl amides of various fatty acids, particularly the dimethyl amides; and glycol ethers such as n-butyl ether, ethyl ether or diethylene glycol methyl ether, and triethylene glycol methyl ether and the like. Mixtures of two or more organic liquids can also be used in preparing the emulsifiable concentrate. Organic liquids include xylene, and propyl benzene fractions, with xylene being most preferred in some cases. Surface active dispersing agents are typically employed in liquid formulations and in an amount of 0.1 to 20 percent by weight based on the combined weight of the emulsifying agents. The formulations may also contain other compatible additives, for example plant growth regulators and other biologically active compounds used in agriculture.
    [038] Aqueous suspensions comprise suspensions of one or more water-insoluble pesticide active ingredients dispersed in an aqueous vehicle at a concentration in the range of about 5 to about 50 percent by weight, based on the total weight of the aqueous suspension. Suspensions are prepared by finely grinding one or more of the pesticide active ingredients, and vigorously mixing the ground material into a vehicle comprising water and surfactants chosen from the same types discussed above. Other components, such as inorganic salts and synthetic or natural gums, can also be added to increase the density and viscosity of the aqueous vehicle. It is often more effective to grind and mix at the same time by preparing the aqueous mixture and homogenizing it in an implement such as a sand mill, ball mill, or piston type homogenizer.
    [039] Aqueous emulsions comprise emulsions of one or more water-insoluble pesticide active ingredients emulsified in an aqueous vehicle at a concentration typically in the range of about 5 to about 50 percent by weight, based on the total weight of the aqueous emulsion . If the pesticide active ingredient is a solid it needs to be dissolved in a suitable water-immiscible solvent prior to preparation of the aqueous emulsion. Emulsions are prepared by emulsifying the liquid pesticide active ingredient or water-immiscible solution thereof in an aqueous medium, typically with the inclusion of surfactants that aid in the formation and stabilization of the emulsion as described above. This is often accomplished with the aid of vigorous mixing provided by high-shear mixers or homogenisers.
    [040] The compositions of the present disclosure can also be granular formulations, which are particularly useful for soil applications. Granular formulations typically contain from about 0.5 to about 10 percent by weight, based on the total weight of the granular formulation of the pesticide active ingredient (or pesticide active ingredients), dispersed in an inert carrier consisting entirely of, or largely in roughly divided inert material, such as attapulgite, bentonite, diatomite, clay, or a similar economic substance. Such formulations are normally prepared by dissolving the pesticidal active ingredients in a suitable solvent and applying them to a granular carrier that has been preformed to the appropriate particle size, in the range of from about 0.5 to about 3 mm. A suitable solvent is a solvent in which the compound is substantially or completely soluble. Such formulations can also be prepared by making a mass or slurry of carrier and compound and solvent, and crushing and drying to obtain the desired granular particle.
    [041] Dusts can be prepared by intimately mixing one or more of the pesticide active ingredients in powder form with a suitable dusty agricultural carrier, such as, for example, kaolin clay, ground volcanic rock, talc, ground bark and the like. Dusts may suitably contain from about 1 to about 10 percent by weight of the compounds, based on the total weight of the dust.
    [042] The formulations may additionally contain adjuvant surfactants and polymers to enhance adhesion and fluidity and decrease dust removal from active ingredients. These adjuvants can optionally be employed as a component of the formulation or as a tank mix. The amount of adjuvant surfactant will typically range from 0.01 to 1.0 percent by volume, based on a spray volume of water, preferably from 0.05 to 0.5 percent by volume. Suitable adjuvant surfactants include, however, without limitation ethoxylated nonyl phenols, ethoxylated natural or synthetic alcohols, salts of the sulfosuccinic acid esters, ethoxylated organosilicones, ethoxylated fatty amines, and mixtures of surfactants with vegetable and mineral oils. The formulations may also include oil-in-water emulsions, such as those disclosed in U.S. Patent Application Serial No. 11/495,228, which disclosure is expressly incorporated by reference herein.
    [043] The formulations may optionally include combinations that contain other pesticidal compounds. Such additional pesticide compounds may be fungicides, insecticides, nematicides, miticides, arthropodicides, bactericides or combinations thereof that are compatible with the mixtures of the disclosure described herein in the medium selected for application, and not antagonistic to the activity of the present mixtures. Consequently, in such embodiments, the other pesticide compound is employed as a supplemental toxic substance for the same or different pesticide use. The mixtures of the present disclosure and the pesticidal compound in the combination may generally be present in a weight ratio of 1:100 to 100:1.
    [044] The term "polymer" or "polymeric material" as used in this disclosure means either a single polymer or a combination of different polymers or a copolymer. The particle comprises from about 50% to about 99% by weight of the polymeric material, preferably from about 50% to about 90% by weight.
    [045] Examples of polymers suitable for the practice of this disclosure include, but are not limited to, the following non-exhaustive list of polymers (and copolymers and blends thereof): poly(methylmethacrylate); poly(lactic acid) (Chronopols 50, 95, and 100) and copolymers such as poly(lactic acid-glycolic acid) copolymers (Lactel BP-400) and blends with polystyrene, for example; cellulose acetate butyrate; polystyrene); hydroxybutyric acid-hydroxyvaleric acid copolymers (Biopol D400G); styrene maleic anhydride copolymers (SMA 1440 A Resin, Sartomer Co.); poly(methyl vinyl ether-maleic acid); poly(caprolactone); poly(n-amylmethacrylate); wood rosin; polyanhydrides, e.g., poly(sebacic anhydride), poly(valeric anhydride), poly(trimethylene carbonate), etc., and copolymers such as poly(carboxyphenoxypropane-sebacic acid), poly(fumaric acid-sebacic acid), etc. ; polyorthoesters; poly(cyanoacrylates); poly(dioxanone); ethylcellulose; ethyl vinyl acetate polymers and copolymers; poly(ethylene glycol); poly(vinylpyrrolidone); acetylated mono, di and triglycerides; poly(phosphazene); chlorinated natural rubber; vinyl polymers and copolymers; polyvinyl chloride; hydroxyalkylcelluloses; polybutadiene; polyurethane; vinylidene chloride polymers and copolymers; styrene-butadiene copolymers; styrene acrylic copolymers; vinyl acetate polymers and copolymers (for example, vinyl acetate-ethylene copolymers (Vinumuls) and vinyl acetate-vinylpyrrolidone copolymers; alkylvinyl ether polymers and copolymers; cellulose acetate phthalates; ethyl vinyl phthalates; cellulose triacetate; polyanhydrides; polyglutamates; poly(hydroxy butyrates); acrylic polymers (Rhoplexes); alkyl acrylate polymers and copolymers; aryl acrylate polymers and copolymers; aryl methacrylate polymers and copolymers; poly(caprolactam) (i.e., the counterparts containing nitrogen for caprolactones); epoxy/polyamine epoxy/polyamides; polyvinyl alcohol polymers and copolymers; polyvinyl alcohol polymers and copolymers; silicones; polyesters (for oil-based strands, including alkyds); phenolics (polymers and copolymers with oils) drying).
    [046] In one embodiment, the polymer used in the compositions of the present disclosure is selected from the group consisting of poly(methylmethacrylate), poly(lactic acid), poly(lactic acid-glycolic acid) copolymers, cellulose acetate butyrate , poly(styrene), hydroxybutyric acid-hydrovaleric acid copolymers, styrene maleic anhydride copolymers, poly(methyl vinyl ether-maleic acid), poly(caprolactone), poly(n-amylmethacrylate), wood rosin, polyanhydrides, polyorthoesters, poly(cyanoacrylates), poly(dioxanone), ethylcellulose, ethylvinyl acetate polymers, poly(ethylene glycol), polyvinylpyrrolidone, acetylated mono, di and trigylcerides, poly(phosphazene), chlorinated natural rubber, vinyl polymers, polyvinyl chloride, hydroxyalkylcelluloses, polybutadiene, polyurethane, vinylidene chloride polymers, styrene-butadiene copolymers, styrene acrylic copolymers, alkylvinylether polymers, cellulose acetate phthalates, e. tilvinyl, cellulose triacetate, polyanhydrides, polyglutamates, poly(hydroxy butyrates), polyvinyl acetate, vinyl acetate-ethylene copolymers, vinyl acetate-vinylpyrrolidone copolymers, acrylic polymers, alkyl acrylate polymers, aryl acrylate polymers , aryl methacrylate polymers, poly(caprolactam), epoxy resins, polyamine epoxy resins, polyamides, polyvinyl alcohol polymers, polyalkyd resins, phenolic resins, abietic acid resins, silicones, polyesters, and copolymers and combinations thereof.
    [047] Preferred polymers include poly(methylmethacrylate), poly(lactic acid) (Chronopols 50, 95 or 100) and combinations with polystyrene, poly(lactic acid-glycolic acid) copolymers (Lactel BP-400), acetate butyrate. cellulose and poly(styrene).
    [048] Compounds of Formula I are effective in use with plants in a disease-inhibiting and phytologically acceptable amount. The term "disease inhibiting and phytologically acceptable amount" refers to an amount of a compound that kills or inhibits the plant disease for which control is desired, but is not significantly toxic to the plant. generally from about 0.5 to about 500 g ai/100 kg of seed. The exact amount of a compound of Formula I required varies with the fungal disease to be controlled, with the type of formulation employed, with the method of application, with the time of application, with the particular plant species, with the climatic conditions and the like. The dilution and application rate will depend on the type of equipment used, the method and frequency of application desired and the diseases to be controlled.
    [049] A compound of Formula I can also be combined with agricultural fungicides to form fungicide mixtures and synergistic mixtures thereof and can be applied to a seed. Fungicidal mixtures are often applied to control a wider range of undesirable diseases. When used in combination with another fungicide (or fungicides), a compound of Formula I can be formulated with the other fungicide (or fungicides), tank mixed with the other fungicide (or fungicides) or applied sequentially with the other fungicide (or fungicides ) in a seed. Such other fungicides include amethoctradine, azoxystrobin, Bacillus subtilis, benalaxyl, benomyl, bentiavalcarb-isopropyl, bitertanol, bixafen, boscalide, capitan, carbendazim, carboxyne, carpropamide, chlorothalonil, Coniothyrium minitans, copper hydroxide, copper octanoate , copper sulfate, copper sulfate (tribasic), cuprous oxide, cyazofamid, cyflufenamide, cyproconazole, cyprodinil, diethofencarb, difenoconazole, dimethomorph, dimoxystrobin, enestrobin, epoxiconazole, ethaboxam, famoxadone, fenamidone, phenamilazole, phenarimol , flumorph, fluopicolide, fluopyram, fluoxastrobin, fluquinconazole, flusilazol, fluthianil, flutolanil, flutriafol, fluxapyroxad, fosetyl, fosetyl aluminum, guazatine, hexaconazole, hyexazole, imazalil, imazalil sulfate, imibenconazole, triphenacetate, iminoctadine iprobenphos, iprodione, iprovalicarb, isopirazam, isothianil, mancozeb, mandipropamide, m anebe, metalaxyl, mefenoxam, metalaxyl-M, methiconazole, metasulfocarb, methyl iodide, methyl isothiocyanate, metiram, metominostrobin, metrafenone, myclobutanil, ofurace, oryastrobin, oxadixyl, copper oxine, picocloade, penconxiazole, penflubine , procymidone, propamocarb, propamocarb hydrochloride, propiconazole, proquinazid, prothioconazole, pyraclostrobin, pyramethostrobin, pyraoxystrobin, pyrazolophos, pyribencarb, pyrimethanil, sedaxane, silthiofam, simeconazole, thiroxamine, tetraconthiazole, tefbuconazole , tolclophos-methyl, triadimenol, triazoxide, tricyclazole, trifloxystrobin, triticonazole, zoxamide, Trichoderma spp., 5-fluorocytosine and pro-fungicides thereof, picolinamide UK-2A and derivatives thereof.
    [050] Additionally, a compound of Formula I can be combined with other pesticides, which include insecticides, nematocides, miticides, arthropodicides, bactericides or combinations thereof that are compatible with the compound of Formula I in the medium selected for application, and are not antagonistic to the activity of the compound of Formula I to form pesticide mixtures and synergistic mixtures thereof. A compound of Formula I can be applied in combination with one or more other pesticides to control a wider variety of unwanted pests. When used in combination with other pesticides, the compound of Formula I can be formulated with the other pesticide (or pesticides), tank mixed with the other pesticide (or pesticides) or applied sequentially with the other pesticide (or pesticides) on a seed. . Typical insecticides include, but are not limited to: antibiotic insecticides such as allosamidine and thuringiensin; macrocyclic lactone insecticides such as spinosad and spinetoram; avermectin insecticides such as abamectin, doramectin, emamectin, eprinomectin, ivermectin and selamectin; milbemycin insecticides such as lepimectin, milbemectin, milbemycin oxime and moxidectin; carbamate insecticides such as bendiocarb and carbaryl; benzofuranyl methylcarbamate insecticides such as benfuracarb, carbofuran, carbosulfan, decarbofuran and furathiocarb; dimethylcarbamate, dimitan, dimethylan, hikincarb and pirimicarb insecticides; Carbamate oxime insecticides, such as alanicarb, aldicarb, aldoxycarb, butocarboxim, butoxycarboxim, methomyl, nitrilacarb, oxamyl, tazimcarb, thiocarboxim, thiodicarb and thiophanoxy; phenyl methylcarbamate insecticides such as alixicarb, aminocarb, bufencarb, butacarb, carbanolate, chloethcarb, dicresyl, dioxacarb, EMPC, ethiofencarb, fenetacarb, fenobucarb, isoprocarb, methiocarb, metolcarb, probexacarb, probexacarb, xurmecarb, xurmecarb ; dehydrating insecticides such as boric acid, diatomaceous earth and silica gel; diamide insecticides such as chlorantraniliprole, cyantraniliprol and flubendiamide; dinitrophenolic insecticides such as dinex, dinoprop, dinosam and DNOC; fluorine insecticides such as barium hexafluorosilicate, cryolite, sodium fluoride, sodium hexafluorosilicate and sulfluramide; Formamidine insecticides such as amitraz, chlordimeform, formetanate and iormparanate, fumigant insecticides such as acrylonitrile, carbon disulfide, carbon tetrachloride, chloroform, chloropicrin, para-dichlorobenzene, 1,2-dichloropropane, ethyl formate, ethylene dibromide, ethylene dichloride, ethylene oxide, hydrogen cyanide, iodomethane, methyl bromide, methylchloroform, methylene chloride, naphthalene, phosphine, sulfuryl fluoride and tetrachloroethane; inorganic insecticides such as borax, calcium polysulfide, copper oleate, mercury chloride, potassium thiocyanate and sodium thiocyanate; chitin synthesis inhibitors such as bistrifluron, buprofezine, chlorfluazuron, cyromazine, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluron, teflubenzuron and triflumuron; juvenile hormone simulants such as epofenonane, fenoxycarb, hydroprene, quinoprene, metoprene, pyriproxyfen and triprene; juvenile hormones, such as juvenile hormone I, juvenile hormone II, and juvenile hormone III; ecdysis hormone agonists such as chromafenozide, halofenozide, methoxyfenozide and tebufenozide; ecdysis hormones such as a-ecdysone and ecdysterone; ecdysis inhibitors such as diofenolan; precocious, such as precocious I, precocious II and precocious III; unclassified insect growth regulators such as dicyclanil; nereistoxin analogue insecticides such as bemultape, cartape, thiocyclam and thiosultape; nicotinoid insecticides such as flonicamid; nitroguanidine insecticides such as clothianidin, dinotefuran, imidacloprid and thiamethoxam; nitromethylene insecticides such as nitempiram and nithiazine; pyridylmethylamine insecticides such as acetamiprid, imidacloprid, nitempiram and thiacloprid; organochlorine insecticides such as bromine-DDT, camphechlor, DDT, pp'-DDT, ethyl-DDD, HCH, gamma-HCH, lindane, methoxychlor, pentachlorophenol and TDE; cyclodiene insecticides such as aldrin, bromocyclene, chlorbicyclene, chlordane, chlordecone, dieldrin, dilor, endosulfan, alpha-endosulfan, endrin, HEOD, heptachlor, HHDN, isobenzane, isodrine, kelevan and mirex; organophosphate insecticides, such as bronfenvinphos, chlorfenvinphos, crotoxyphos, dichlorvos, dicrotophos, dimethylvinphos, fospirate, heptenophos, methocrotophos, mevinphos, monocrotophos, naled, naphthalophos, tetrachlorvin TEPP and propaphos; organothiophosphate insecticides such as dioxabenzophos, phosmethylane and fentoate; aliphatic organothiophosphate insecticides such as acethiom, amiton, cadusaphos, chloroxiphos, chlormephos, demefion, demefion-O, demefion-S, demeton, demeton-O, demeton-S, demeton-methyl, demeton-O-methyl, demeton -methyl, demeton- S-methylsulfone, disulfoton, ethion, ethoprophos, IPSP, isothioate, malathion, methacrylphos, oxidemeton-methyl, oxideprophos, oxydisulfoton, phorate, sulfotep, terbuphos and thiometon; aliphatic amide organothiophosphate insecticides such as amidition, cyanoate, dimethoate, ethoate-methyl, formotion, mecarbam, omethoate, protoate, sophamide and vamidothion; organothiophosphate oxime insecticides such as chlorphoxime, phoxime and methyl phoxime; heterocyclic organothiophosphate insecticides such as azamethiphos, coumaphos, coumitoate, dioxation, endothion, menazone, morphothion, phosalone, pyraclophos, pyridafenthion and quinothion; benzothiopyran organothiophosphate insecticides such as dichrophos and thichrophos; benzotriazine organothiophosphate insecticides such as azinphos-ethyl and azinphos-methyl; isoindole organothiophosphate insecticides, such as dialyphos and phosmet; isoxazole organothiophosphate insecticides such as isoxathion and zolaprophos; pyrazolopyrimidine organothiophosphate insecticides such as chlorprazophos and pyrazolophos; pyridine organothiophosphate insecticides such as chlorpyriphos and chlorpyriphos-methyl; pyrimidine organothiophosphate insecticides such as butathiophos, diazinone, ethrphos, lyrinfos, pyrimiphos-ethyl, pyrimiphos-methyl, primidophos, pyrimitate and tebupyrimphos; quinoxaline organothiophosphate insecticides such as quinalphos and quinalphos-methyl; thiadiazole organothiophosphate insecticides such as atidathion, litidatione, methidathione and protidathion; triazole organothiophosphate insecticides such as isazophos and tinazophos; phenyl organothiophosphate insecticides, such as nitrogen, bromophos, bromophos-ethyl, carbophenothion, chlorthiophos, cyanophos, citioate, dicaptone, diclophenthione, ethaphos, fanfur, fenchlorphos, fenitrothione, fensulfothione, phenthione, methanophenthione, heterophenthione - methyl, fencapton, phosnichlor, profenophos, prothiophos, sulprophos, temephos, trichlormetaphos-3 and trifenophos; phosphonate insecticides such as butonate and trichlorfon; phosphonothioate insecticides such as mecarfon; phenyl ethylphosphonothioate insecticides such as phonophos and trichloronate; phenyl phenylphosphonothioate insecticides such as cyanophenols, EPN and leptophos; phosphoramidate insecticides such as crufomate, fenamiphos, phosthiethane, mephospholam, phospholam and pyrimetaphos; phosphorus amidothioate insecticides such as acephate, isocarbophos, isofenphos, isofenphos-methyl, methamidophos and propetanphos; phosphorodiamide insecticides such as dimefox, mazidox, mipafox and escradan; oxadiazine insecticides such as indoxacarb; oxadiazoline insecticides such as methoxadiazone; phthalimide insecticides such as dialyphos, phosmet and tetramethrin; pyrazole insecticides such as tebufenpyrad, tolefenpyrad; phenylpyrazole insecticides such as acetoprol, ethiprole, fipronil, pyrafluprol, pyriprol and vaniliprole; pyrethroid ester insecticides such as acrinathrin, allethrin, bioallethrin, barthrin, bifenthrin, bioethanometrine, cyclethrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, gamma-cyhalothrin, lambda-cyhalothrin, cypermethrin, alpha-cypermethrin, -cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, dimefluthrin, dimethrin, empentrine, fenfluthrin, phempyrithrin, fenpropathrin, fenvalerate, esfenvalerate, flucitrinate, fluvalinate, tau-fluvalinate, furethrin, mepermethrin, imipromethrin , phenothrin, praletrin, proflutrin, pyresmethrin, resmethrin, bioresmethrin, cismethrin, tefluthrin, terallethrin, tetramethrin, tetramethylfluthrin, tralomethrin and transfluthrin; pyrethroid ether insecticides such as ethofenproxy, flufenproxy, halfenproxy, protrifenbute and esilafluofen; pyrimidinamine insecticides such as flufenerim and pyrimidifen; pyrrole insecticides such as chlorfenapyr; tetramic acid insecticides such as spirotetramate; tetronic acid insecticides such as spiromesifene; thiourea insecticides such as diafentiuron; urea insecticides such as flucofuron and sulcofuron; and unclassified insecticides such as closantel, copper naphthenate, crotamiton, EXD, fenazaflor, fenoxacrim, hydramethylnone, isoprothiolane, malonobene, metaflumizone, nifluridide, plifenate, pyridaben, pyridalyl, pyrifluquinazone, rafoxanide, and trifluoride, any combinations of the same.
    [051] Additionally, a compound of Formula I can be combined with herbicides that are compatible with the compound of Formula I in the medium selected for application, and are not antagonistic to the activity of the compound of Formula I to form pesticide mixtures and synergistic mixtures thereof . The compound of Formula I can be applied in combination with one or more herbicides to control a wide variety of unwanted plants. When used in combination with herbicides, a compound of Formula I can be formulated with the herbicide (or herbicides), tank mixed with the herbicide (or herbicides), or applied sequentially with the herbicide (or herbicides). Typical herbicides may include, but are not limited to: starch herbicides such as alidochlor, beflubutamide, benzadox, benzipram, bromobutide, cafenstrol, CDEA, ciprazole, dimethenamid, dimethenamid-P, diphenamide, epronaz, ethnipromide, fentrazamide, flupoxam, hunger , halosaphen, isocarbamide, isoxaben, napropamide, naptalam, petoxamide, propizamide, quinonamide and tebutam; anilide herbicides such as chloranocril, cisanilide, clmeprop, cypromide, diflufenican, etobenzanide, fenasulam, flufenacet, flufenican, mefenacet, mefluidide, metamifop, monalide, naproanilide, pentanochlor, picolinafen and propanil; arylalanine herbicides such as benzoylprop, flamprop and flamprop-M; chloroacetanilide herbicides such as acetochlor, alachlor, butachlor, butenachlor, delachlor, dietityl, dimethachlor, metazachlor, metolachlor, S-metolachlor, pretilachlor, propachlor, propisochlor, prinachlor, terbuchlor, thenylchlor and xylachlor; sulfonanilide herbicides such as benzofluor, perfluidone, pyrimisulfan and profluazole; sulfonamide herbicides such as asulam, carbasulam, fenasulam and oryzalin; thioamide herbicides such as chlorthiamide; antibiotic herbicides such as bilanaphos; benzoic acid herbicides such as chloramben, dicamba, 2,3,6-TBA and tricamba; pyrimidinyloxybenzoic acid herbicides such as bispyribac and pyriminobac; pyrimidinylthiobenzoic acid herbicides such as pyrithiobac; phthalic acid herbicides such as chlorthal; picolinic acid herbicides such as aminopyralide, clopyralide and picloram; quinolinecarboxylic acid herbicides such as quinchlorac and quinmerac; arsenic herbicides such as cacodylic acid, CMA, DSMA, hexaflurate, MAA, MAMA, MSMA, potassium arsenite and sodium arsenite; benzoylcyclohexanedione herbicides such as mesotrione, sulcotrione, tefuryltrione and tembotrione; benzofuranyl and alkylsulfonate herbicides, such as benfuresate and ethofumesate; benzothiazole herbicides such as benzazoline; carbamate herbicides such as asulam, carboxazole chlorprocarb, dichlormate, fenasulam, carbutylate and terbucarb; carbanilate herbicides such as barbam, BCPC, carbasulam, carbetamide, CEPC, chlorbufam, chlorpropam, CPPC, desmedipham, fenisofam, phenmedipham, phenmedipham-ethyl, profam and swep; cyclohexane oxime herbicides such as aloxidim, butroxydim, clethodim, cloproxydim, cyclooxydim, profoxydim, sethoxydim, tepraloxydim and tralkoxydim; cyclopropylisoxazole herbicides such as isoxachlortol and isoxaflutol; dicarboximide herbicides such as cinidom-ethyl, flumezim, flumiclorac, flumioxazim and flumipropim; dinitroaniline herbicides such as benfluralin, butralin, dinitramine, ethalfluralin, fluchloralin, isopropaline, metalpropaline, nitralin, oryzalin, pendimethalin, prodiamine, profluralin and trifluralin; dinitrophenol herbicides such as dinofenate, dinoprop, dinosam, dinosab, dinoterb, DNOC, etinophen and medenoterb; diphenyl ether herbicides such as ethoxyphene; nitrophenyl ether herbicides such as acifluorfen, aclonifen, biphenoxy, chlomethoxyphen, chlornitrofen, ethnipromide, fluorodifen, fluoroglycofen, fluoronitrofen, fomesafen, furyloxyphene, halofluorfen, lactophene, nitrofen, nitrofluorophen, and nitrofen; dithiocarbamate herbicides such as dazomete and metam; aliphatic halogenated herbicides such as alorac, chloropon, dalapon, flupropanate, hexachloroacetone, iodomethane, methyl bromide, monochloroacetic acid, SMA and TCA; imidazolinone herbicides such as imazametabenzo, imazamox, imazapique, imazapyr, imazaquin and imazethapyr; inorganic herbicides such as ammonium sulfamate, borax, calcium chlorate, copper sulphate, ferrous sulphate, potassium azide, potassium cyanide, sodium azide, sodium chlorate and sulfuric acid; nitrile herbicides such as bromobonil, bromoxynil, chloroxynil, dichlobenil, iodobonil, ioxynil and pyraclonil; organophosphate herbicides such as amiprophos-methyl, anilophos,bensulide, bilanafos, butamiphos, 2,4-DEP, DMPA, EBEP, phosamine, glufosinate, glufosinate-P, glyphosate and piperophos; phenoxy herbicides such as bromophenoxim, clmeprop, 2,4-DEB, 2,4-DEP, difenopentem, disul, erbom, ethnipromide, fenteracol and trifopsime; oxadiazoline herbicides such as methazol, oxadiargyl, oxadiazone; oxazole herbicides such as phenoxasulfone; phenoxyacetic herbicides such as 4-CPA, 2,4-D, 3,4-DA, MCPA, MCPA-thioethyl and 2,4,5-T; phenoxybutyric herbicides such as 4-CPB, 2,4-DB, 3,4-DB, MCPB and 2,4,5-TB; phenoxypropionic herbicides such as cloprop, 4-CPP, dichlorprop, dichlorprop-P, 3,4-DP, fenoprop, mecoprop and mecoprop-P; aryloxyphenoxypropionic herbicides, such as chlorazifop, clodinafop, clofop, cyhalofop, diclofop, fenoxaprop, fenoxaprop-P, fentiaprop, fluazifop, fluazifop-P, haloxyfop, haloxyfop-P, isoxapyrifop, metaquizalofop, propoxyfop; phenylenediamine herbicides such as dinitramine and prodiamine; pyrazole herbicides such as pyroxasulfone; benzoylpyrazole herbicides such as benzofenape, pyrasulfotol, pyrazolinate, pyrazoxifene and topramezone; phenylpyrazole herbicides such as fluazolate, nipyraclofen, pioxaden and pyraflufen; pyridazine herbicides such as credazine, pyridafol and pyridate; pyridazinone herbicides such as brompirazone, chloridazone, dimidazone, flufenpyr, metflurazone, norflurazone, oxapyrazone and pidanone; pyridine herbicides such as aminopyralide, cliodinate, clopyralide, dithiopyr, fluroxypyr, haloxidine, picloram, picolinaphene, pyrichlor, thiazopyr and triclopyr; pyrimidinediamine herbicides such as iprimidam and thiochlorim; quaternary ammonium herbicides such as cyperquat, dietanquat, difenzoquat, diquat, morphanquat and paraquat; thiocarbamate herbicides such as butylate, cycloate, dialate, EPTC, esprocarb, ethiolate, isopolinate, methiobencarb, molinate, orbencarb, pebulate, prosulfocarb, pyributicarb, sulphalate, thiobencarb, thiocarbazil, triallate, and vernolate; thiocarbonate herbicides such as dimexane, EXD and proxane; thiourea herbicides such as methiuron; triazine herbicides such as dipropetrin, indaziflam, triaziflam and trihydroxytriazine; chlorotriazine herbicides such as atrazine, chlorazine, cyanazine, cyprazine, eglinazine, ipazine, mesoprazine, procyazine, proglinazine, propazine, sebuthylazine, simazine, terbuthylazine and trietazine; methoxytriazine herbicides such as atratone, memethone, prometone, secbumetone, simetone and terbumetone; methylthiotriazine herbicides such as ametrine, aziprothrin, cyanatrine, desmethrin, dimethathrin, methoprothrin, promethrin, simethrin and terbutrin; triazinone herbicides such as ametridione, amibuzine, hexazinone, isomethiozine, metamitron and metribuzine; triazole herbicides such as amitrol, cafenstrol, epronaz and flupoxam; triazolone herbicides such as amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone and thiencarbazone-methyl; triazolpyrimidine herbicides such as chloransulam, diclosulam, florasulam, flumetsulam, metosulam, penoxsulam and piroxsulam; uracil herbicides such as benzfendizone, bromacil, butaphenacyl, flupropacil, isocil, lenacil, saflufenacyl and terbacil; urea herbicides such as benzthiazuron, cumylurone, cycluron, dichloralurea, diflufenzopyr, isonoruron, isouron, metabenzthiazuron, monisouron and noruron; phenylurea herbicides, such as anisuron, butuone, chlorbromurone, chlorethurone, chlorotolurone, chloroxuron, daimuron, difenoxuron, dimefurone, diuron, phenuron, fluometurone, fluothiuron, isoproturone, linuron, daimuron, methiurone, methiuron neburone, paraflurone, phenobenzuron, sidurone, tetraflurone and thidiazuron; pyrimidinylsulfonylurea herbicides, such as amidosulfuron, azimsulfuron,bensulfurone, chlorimuron, cyclosulfamuron, ethoxysulfuron, propyrissulfuron, pyrazosulfuron, rimsulfuron, sulfometurone, sulfosulfuron, and trifloxysulfuron; triazinylsulfonylurea herbicides, such as chlorsulfuron, kinesulfuron, ethametsulfuron, iodosulfuron, metsulfuron, prosulfuron, thifensulfuron, triasulfuron, tribenuron, triflusulfuron and tritosulfuron; thiadiazolylurea herbicides such as butyuron, ethimurone, tebutyuron, thiazaflurone and thidiazuron; and unclassified herbicides such as acrolein, allyl alcohol, aminocyclopyrachlor, azafenidin, bentazone, benzobicyclone, bicyclopyrone, butidazole, calcium cyanamide, cambendichlor, chlorfenac, chlorfenprop, chlorflurazol, chlorflurenol, cinmethylcyanin, clomazone, CPMF, cresol dichlorobenzene, dimepiperate, endothal, fluoromidine, fluridone, flurochloridone, flurtamone, fluthiacet, indanophane, methyl isothiocyanate, OCH, oxaziclomefon, pentachlorophenol, pentoxazone, phenylmercury acetate, prosulfidaline, sulphaline, thiazinium pyriphenylamine tridiphane, trimeturone, trippropindan and tritack.
    [052] The seed treatment mixture may also comprise or may be applied together and/or sequentially with additional active compounds. Such additional compounds can be plant health stimulants, such as organic compounds, inorganic fertilizers or micronutrient donors, or other preparations that influence plant growth, such as inoculants.
    [053] In another modality, the seed treatment mixture can also comprise or can be applied together and/or sequentially with other biological organisms, such as, however, without limitation to the group consisting of Bacillus strains, for example Bacillus subtilis var. amyloliquefaciens FZB24 (TAEGRP®) and Bacillus amyloliquefaciens FZB42 (RHIZO VITAL®), and/or mutants and metabolites of the respective strains that exhibit activity against insects, mites, nematodes and/or phytopathogens.
    [054] Another embodiment of the present disclosure is a method for controlling or preventing fungal attack. That method comprises applying to the seed a fungicidally effective amount of a compound of Formula I. A compound of Formula I is suitable for treating various plants at fungicidal levels while exhibiting low phytotoxicity. The compost can be useful in both a protective and an eradicating way.
    [055] The compounds of Formula I have been found to have significant fungicidal effects, particularly for agricultural use. The compounds of Formula I are particularly effective for use in agricultural crops and horticultural plants. Additional benefits may include, but are not limited to improving the health of a plant; improve the yield of a plant (eg increased biomass and/or increased content of valuable ingredients); improve the vigor of a plant (eg improved plant growth and/or greener leaves); improve the quality of a plant (eg improved content or composition of certain ingredients); and improve the plant's abiotic and/or biotic stress tolerance.
    [056] It will be understood by those in the art that the effectiveness of compounds of Formula I for the following fungi sets the standard for general utility of the compounds as fungicides.
    [057] Compounds of Formula I have broad ranges of activity against fungal pathogens. Exemplary pathogens may include, but are not limited to, wheat septoria (Zymoseptoria tritici), sugar beet cercosporiosis (Cercospora beticola), peanut seagrass (Cercospora arachidicola and Cercosporidium personatum). The exact amount of active material to be applied is dependent not only on the specific formulation that is applied, but also on the particular action desired, the fungal species to be controlled and their stage of growth, as well as the part of the plant or other product to be contacted with the compound.
    [058] Any desired range or value granted herein may be extended or changed without losing the intended effects, as is apparent to the subject matter expert for an understanding of the teachings in this document.
    [059] EXAMPLES
    [060] Evaluation of Fungal Activity as a Seed Treatment for Wheat Septoria (Zymoseptoria tritici; Bayer code SEPTTR): Seeds from wheat cultivar "Yuma" were treated with seed dye and a 10% compound 1 suspension concentrate formulation. at rates of 300, 100, 33.3, 11, 3.7 and 0 grams of active ingredient/100 kg of seeds (g ai/100 kg of seeds). Treated seeds were planted in pots containing 50% mineral soil/50% soilless meter mixture 12 days after treatment, with 10 seeds per pot, and grown in a greenhouse at 20°C. Four 7-day seedling pots were inoculated with an aqueous spore suspension of Z. tritici and after inoculation the plants were kept at 100% relative humidity> to allow spores to germinate and infect the leaf. The plants were then transferred to a greenhouse set at 20°C for disease development.
    [061] The activity of various compounds of Formula I, when evaluated in these experiments, is shown in Table 2. The efficacy of compounds of Formula I in controlling disease was determined by evaluating disease severity in treated plants and then converting severity is measured as a percentage of control based on the level of disease in untreated inoculated plants.
    [062] Test results indicated that compound 1 was quite active against Z. tritici, providing 93% disease control at the rate of 11 gai/100 kg of seeds.
    [063] Leaf disease control with these seed treatment applications demonstrates that the experimental compound is collected in the xylem and redistributed to leaves in an amount sufficient to provide protective disease control from a seed treatment. Additionally, there was no evidence of growth retardation or phytotoxicity from compound 1 applications, even at the highest rates tested. Excellent disease control without phytotoxicity indicates that the chemical classes represented by the compounds of Formula I have potential utility as seed treatments.
    [064] TABLE 1. BIOLOGICAL ACTIVITY CLASSIFICATION SCALE

    [065] TABLE 2. FOLIARY DISEASE CONTROL OF SEED TREATMENTS USING FORMULA I COMPOUNDS

    [066] Compound No. - Compound Number
    [067] *g ai/100 kg of seeds - grams of active ingredient per 100 kilograms of seeds
    [068] SEPTTR - Wheat Septoria (Zymoseptoria tritici).
    权利要求:
    Claims (13)
    [0001]
    1. Method for treating a plant seed to produce a plant resistant to fungal attack, characterized in that the plant seed is treated with a compound of Formula I.
    [0002]
    A method for treating a plant seed to produce a plant resistant to fungal attack, according to claim 1, characterized in that the compound of Formula I is applied at a rate of about 0.5 to about 500 grams per 100 kilograms of seed.
    [0003]
    A method for treating a plant seed to produce a plant resistant to fungal attack, according to claim 1, characterized in that the compound of Formula I is applied at a rate of about 3.7 to about 300 grams per 100 kilograms of seed.
    [0004]
    4. Method for treating a seedling to produce a plant resistant to fungal attack, characterized in that the seedling is treated with a compound of Formula I,
    [0005]
    A method for treating a plant seed or seedling to produce a plant resistant to fungal attack, according to claims 1 to 4, characterized in that: a) the seed or seedling to be treated is a wheat seed or seedling (Triticum sp.; TRZSS), sugar beet seed or seedling (BEAVA), or peanut seed or seedling (ARHHY); and/orb) the fungal pathogen is selected from the group consisting of the causal agent of wheat leaf spot (Zymoseptoria tritici), sugar beet leaf spot (Cercospora beticola) and peanut leaf spot (Cercospora arachidicola and Cercosporidium personatum).
    [0006]
    6. Method to protect a plant from fungal attack, characterized in that it comprises the application of a compound of Formula I, as a liquid or solid formulation to the seedling environment,
    [0007]
    A method of protecting a plant from fungal attack, according to claim 6, characterized in that a) the method further comprises applying one or more additional fungicides, b) the method further comprises applying one or more herbicides to eradicate unwanted vegetation, and ) the method further comprises applying one or more insecticides to further protect the plant against insect attack, and/or) the method further comprises applying one or more additional plant health stimulants selected from the group consisting of organic compounds , inorganic fertilizers or micronutrient donors, biocontrol agents and inoculants.
    [0008]
    8. Use of a compound of Formula I characterized by being to treat a plant seed or seedling to produce a plant resistant to fungal attack,
    [0009]
    9. Use of a compound of Formula I characterized in that it is to protect a plant from fungal attack comprising applying the compound of Formula I, as a liquid or solid formulation, to the seedling environment, wherein R1 and R2 are each -CH3.
    [0010]
    10. Use of a compound of Formula I characterized as being for the manufacture of a composition for treating a plant seed or seedling to produce a plant resistant to fungal attack,
    [0011]
    11. Use of a compound of Formula I characterized by being for the manufacture of a liquid or solid formulation to protect a plant from fungal attack, wherein the liquid or solid formulation is formulated for application in a seedling environment, and wherein R1 and R2 are each -CH3.
    [0012]
    12. Seed treatment blend or composition characterized by comprising a compound of Formula I and an adjuvant surfactant or polymer,
    [0013]
    A seed treatment mixture or composition according to claim 12, characterized in that: a) the seed treatment mixture is a tank mix, or b) the seed treatment composition is a wettable powder, granules dispersible in water, an emulsifiable concentrate, aqueous suspensions, a suspension concentrate, an aqueous emulsion, an emulsion in water or a suspension emulsion.
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    同族专利:
    公开号 | 公开日
    MA41272A|2017-10-31|
    AR103283A1|2017-04-26|
    ZA201704838B|2020-11-25|
    KR20170105527A|2017-09-19|
    AU2015369906C1|2020-10-15|
    AU2015369906A1|2017-07-27|
    CA2971719A1|2016-06-30|
    EP3237389A1|2017-11-01|
    CR20170325A|2017-08-29|
    IL252983D0|2017-08-31|
    IL252983A|2020-03-31|
    ECSP17046205A|2017-09-29|
    CL2017001686A1|2018-02-02|
    PH12017501171A1|2017-12-11|
    JP2020196729A|2020-12-10|
    BR112017013733A2|2018-03-13|
    JP2018508468A|2018-03-29|
    TW201628499A|2016-08-16|
    PE20171098A1|2017-08-07|
    TWI699162B|2020-07-21|
    US20180000082A1|2018-01-04|
    MX2017008370A|2018-04-30|
    AU2015369906A8|2017-08-03|
    EA201791444A1|2017-11-30|
    EP3237389A4|2018-05-30|
    WO2016106138A1|2016-06-30|
    CN107250117A|2017-10-13|
    AU2015369906B2|2020-03-19|
    CO2017007059A2|2017-10-10|
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    法律状态:
    2021-03-09| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|
    2021-06-15| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2021-08-10| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/12/2015, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    US201462096301P| true| 2014-12-23|2014-12-23|
    US62/096,301|2014-12-23|
    PCT/US2015/066756|WO2016106138A1|2014-12-23|2015-12-18|5-fluoro-4-imino-3--1--3,4-dihydropyrimidin-2-one as a seed treatment|
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